| || || Kacivakanadina, Ilaisa|
| || || Antibiotic potential of bioactive compounds from a marine streptomyces isolated from Solomon Islands sediments|
Institution: The University of the South Pacific
Subject: Streptomyces | Solomon Islands, Antibiotcs, Bioactive compounds | Solomon Islands, Marine pharmacology | Solomon Islands
Call No.: Pac QR 82 .S8 K33 2018
Copyright:10-20% of this thesis may be copied without the authors written permission
Abstract: Bacterial strain 1903 was isolated and purified from Solomon Islands marine sediment samples. From its morphological features, it was classified as a Streptomyces. The secondary metabolites of strain 1903 were extracted using EtOAc. Bioassay guided purification of the extract produced two known pure compounds; 5- deoxyenterocin and vulgamycin (also known as enterocin). Both compounds were strongly active against WTSA (MIC <1 μg/mL) and in BSA (MIC <1 μg/mL). 5- deoxyenterocin was also active against RRSA (MIC of 250 μg/mL) while vulgamycin showed bioactivity against MRSA (MIC of 250 μg/mL). This report contains the first bio-activity results of 5-deoxyenterocin to be recorded and the first bio-activity results of vulgamycin in the brine shrimp assay to be reported.