| || || Kavora, Wayne Benjamin|
| || || Characterization of secondary metabolites from a marine bacterium isolated from Solomon Islands sponge|
Author:Kavora, Wayne Benjamin
Institution: The University of the South Pacific
Subject: Actinobacteria | Solomon Islands Marine metabolites | Solomon Islands Microbial metabolites | Solomon Islands, Sponges | Solomon Islands
Call No.: Pac QR 82 .A35 K38 2018
Copyright:20-40% of this thesis may be copied without the authors written permission
Abstract: Over the course of this study, a marine bacterium was isolated from the sponge Haliclona fasigera, collected from tropical waters of the Solomon Islands. From this microbe, labeled S-011, two known compounds were isolated. One compound was identified by NMR as 2-aminobenzoic acid (2-AA) or anthranilic acid (AnA), and active against Bacillus oceanisediminis sp. CNY-977. The second compound was identified as 2-phenylacetic acid and was found to be inactive against any of the pathogens tested. The marine bacterium was unable to grow in absence of seawater and was identified as Bacillus sp. S-011, 99% BLAST similarity to Bacillus aquimaris. Biosynthesis of anthranilic acid by Bacillus spp. is not new, however, to the best of our knowledge there has never been any publication on the antibacterial activity of 2-AA from Bacillus spp. neither any report on the biosynthesis of 2-AA by a marine Bacillus sp. nor on the antibacterial activity of a Bacillus-derived anthranilic acid against Bacillus oceanisedimins sp. CNY-977. The findings of this study support three previous studies that reported the biosynthesis of anthranilic acid by three different Bacillus spp. and for the first time, reported the antibacterial activity of a biosynthetically produced 2-AA from a marine Bacillus sp.